abstract |
(57) Abstract: Provided is a useful method for producing the quinuclidine derivative having excellent squalene synthase inhibitory activity. SOLUTION: The formula: (Wherein, R 11 , R 12 , R 13 , R 14 and X have the same meaning as defined above) (5) a) and the formula Wherein the compound (6a) represented by the formula is subjected to a coupling reaction using a palladium catalyst. (Wherein, R 11 , R 12 , R 13 and R 14 have the same meanings as defined above). |