| abstract |
(57) [Summary]nPROBLEM TO BE SOLVED: To provide a matrix metalloprotease (MMP) a compound having an excellent activity inhibitory effect on s), and An MMPs inhibitor, a pharmaceutical composition, and a chemical comprising the same as an active ingredient Provided are a cosmetic composition and a skin external preparation.nSOLUTION: The azabicyclo compound of the formula (I) or a compound thereof salt.nEmbedded imagen (R is H, alkyl, heteroalkyl, aryl, hete Loaryl, arylalkyl, heteroarylalkyl Le, acyl, COOR 1 , Carbamoyl or SO 2 R 2 (R 1 , R 2 Is alkyl, heteroalkyl, aryl, Heteroaryl, arylalkyl or heteroaryl Alkyl); X is methylene, ethylene or propylene; ... Represents a single bond or a double bond. ) |