| abstract |
(57) [Summary] [Problem] Excellent high conductance type calcium-sensitive K Channel opening action and creation of a therapeutic agent for pollakiuria and urinary incontinence based on the action. High conductance calcium sensitive K channel opener. [Formula] [The symbols in the formula have the following meanings. R 1 : an optionally substituted aryl or aromatic heterocyclic group. R 2 : (1) optionally substituted —O-lower alkyl, etc. (2) an optionally substituted -S-lower alkyl or the like; or (3) an amino or cyclic amino group optionally substituted with a lower alkyl. R 3: -H, -CO- nonaromatic heterocyclic group. X: N, CH or CR 4 . R 4 : lower alkyl, —COO-lower alkyl and the like. ] |