http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2003202342-A

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filingDate 2001-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2003-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2003202342-A
titleOfInvention Biochemical sample detection method and detection chip
abstract (57) [Summary] [Problem] Biochemistry that can be visually detected without using a conventional detection method such as a fluorescence method or SPR spectroscopy, can simplify the detection process with good reproducibility, and has a simple process. Provision of sample detection method and detection chip. SOLUTION: The probe DNA in which a modifiable site such as an open end is formed toward a substrate side by forming a loop structure, Hybridization occurs only when the target DNA is present, the loop structure is eliminated, and the probe DNA is extended, so that the above-mentioned open end can be modified. It is possible to visually detect the aggregate of these particle labels on the detection chip, and further, as a second label on the previously provided particle label, another coloring particle, chemical coloring, dye label, etc. By the modification, visual detection can be more easily performed.
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