| abstract |
PROBLEM TO BE SOLVED: To reproduce the appearance of Lewy bodies, abnormal behavior, and decreased dopamine in the brain, into which a double mutant gene of α-synuclein gene which is a gene causing Parkinson's disease is introduced. It is an object to provide a model transgenic mouse. A Parkinson's disease model that reproduces the appearance of Lewy bodies, abnormal behavior, and decreased dopamine in the brain by constructing a double mutant gene of α-synuclein gene and introducing the mutant gene into mice Obtain transgenic mice. |