| abstract |
(57) [Abstract] [Problem] To provide an agent for preventing or treating bone and arthritis. SOLUTION: SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, a compound or a salt thereof that regulates the activity of a protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 7, SEQ ID NO: 9, SEQ ID NO: 11, or SEQ ID NO: 13, SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7, SEQ ID NO: 9. Complementary or substantially complementary to the nucleotide sequence of DNA encoding a protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 11 or SEQ ID NO: 13 or a partial peptide thereof Antisense polynucleotides containing a base sequence or a part thereof can be used as a prophylactic / therapeutic agent for osteoarthritis and the like. |