| abstract |
(57) [Problem] An isoform of the protein drebrin A, And a DNA encoding the same, a cell into which the DNA or protein has been introduced, and a method for screening for an agent that enhances the function of drebrin A or that prevents or treats a disease caused by inhibition of dribulin A function using the cell. thing. SOLUTION: An isoform of drebrin, s-drebulin A, was identified and cloned. The present invention relates to a deletion, substitution or adduct of s-drebrin A and its amino acids; DNAs encoding them; host cells incorporating the DNAs; monoclonal antibodies or polyclonal antibodies specifically binding to the proteins; Or an animal nerve cell into which a protein has been introduced to competitively inhibit the function of drebrin A; and has an effect of enhancing the function of drebrin A or inhibiting or treating a disease caused by inhibition of the function of drebrin A using the animal neuron. It consists of a method for screening substances. |