abstract |
(57) [Problem] To provide a molecule expressed by a human synovial tube. SOLUTION: It mediates lymphocyte binding in humans, A new endothelial cell molecule, VAP-1, is described. Anti-VAP A monoclonal antibody 1B2 is provided by the present invention, as is the hybridoma cell line (DSM ACC2041) producing said antibody. The present invention further provides methods of treating inflammatory and autoimmune diseases by administering a VAP-1 binding compound, such as an anti-VAP-1 antibody. |