| abstract |
PROBLEM TO BE SOLVED: To provide a granular substance such as a microcapsule containing a drug, which does not exhibit an initial release which causes a substantial hindrance, and which exhibits a zero-order release which is practically acceptable for a certain period of time. Provided are a sustained-release preparation and a method for producing the same, and a sustained-release preparation having a high drug content in which a drug is encapsulated in granules such as capsules with good stability, and a method for producing the same. In addition, using a high-performance polymer compound, one of the oil phase or aqueous phase To provide a granular material such as a microcapsule containing the above in a solid phase and a method for producing the same. Furthermore, a granular material having a hollow structure of a microcapsule shape having a single film of a polymer as an envelope capable of containing many bubbles in the fine particles and a selectively high reproducibility of the hollow granular material. To provide a manufacturing method which can be manufactured by using SOLUTION: A granular material such as a capsule is formed by using a polyhydroxyalkanoate having a specific structure, and a drug, an oil phase or an aqueous phase, or a gas phase (hollow portion) used for a target application is contained therein. |