| abstract |
[PROBLEMS] To provide a PPARδ agonist effective for treating hyperlipidemia and atherosclerosis. A PPARδ agonist having the following chemical formula (1): (Wherein, R 1 represents a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group, R 2 represents a hydrogen atom or an alkyl group, and R 3 and R 4 represent a halogen atom, an alkyl group, an alkoxy group, a cyclo group, Represents an alkyl group or a carbamoyl group, or R 3 and R 4 may together form a 5- to 7-membered ring containing 0 to 2 oxygen atoms; X 1 represents a single bond, an oxygen atom or a sulfur atom, X 2 represents a single bond, an oxygen atom, Y represents a carboxyl group or a group which is hydrolyzed in vivo to regenerate a carboxyl group, W 1 and W 2 represents a single bond or an alkylene chain, W 3 represents a single bond, a carbonyl group, or an alkylene group. ) |