| abstract |
(57) To provide a gene therapy method that does not cause an adverse immune response in a subject having an immune response ability to a therapeutic polypeptide. A pharmaceutical composition for inducing immune tolerance in a human subject, comprising a vector comprising a polynucleotide encoding a therapeutic polypeptide, the subject having an immune response ability to the peptide However, by administering the composition to the subject, (i) the therapeutic polypeptide is selectively expressed in the hepatocytes of the subject, and then (ii) the subject is expressed in the therapeutic polypeptide. The pharmaceutical composition as described above, which does not cause a medically significant immune response. |