| abstract |
(57) [Summary] A novel immunostimulatory oligonucleotide composition, A useful method based on the immunostimulatory activity of the oligonucleotide, a neutral oligonucleotide, a useful method using the neutral oligonucleotide, and various uses of the immunoinhibitory oligonucleotide and the immunoinhibitory oligonucleotide. SOLUTION: Formula I: 5 ′ X 1 X 2 CGX 3 X 4 An immunostimulatory oligonucleotide comprising at least one nucleic acid sequence according to 3 ′: wherein CG is an unmethylated CpG dinucleotide that confers an immunostimulatory capacity on said oligonucleotide; at least one of X 1 and X 2 Is a purine; and at least one of X 3 and X 4 One is pyrimidine. |