| abstract |
[PROBLEMS] To provide a novel class of compounds useful as inhibitors of ICE, and pharmaceutically acceptable derivatives thereof. SOLUTION: The present invention provides a new type of compound, an ICE inhibitor represented by the following formula. Here, various substituents are disclosed herein. These compounds are IL-1, apoptosis, IGIF or IFN alone or in combination with other therapeutic or prophylactic agents (eg, antibiotics, immunomodulators or other anti-inflammatory agents) -Can be used for the treatment or prevention of gamma-mediated diseases. According to a preferred embodiment, the compounds of the present invention are ICE And can inhibit the activity of the enzyme. |