| abstract |
(57) [Summary] (Modified) [Problem] To provide a concomitant drug aimed at improving the preventive / therapeutic effect of various diseases and the QOL by a GnRH agonist. A GnRH agonist, a SERM drug, and a SAR A drug selected from the group consisting of M drug, sex hormone synthesis inhibitor, receptor tyrosine kinase inhibitor, bone metabolism regulator, cytokine / chemokine inhibitor, and endothelin receptor antagonist is used in combination. Specific uses include breast cancer, precocious puberty, endometriosis, uterine fibroids, Alzheimer's disease, Cardiovascular disease, menopause, indefinite complaints, cancer metastasis, PM S, dysmenorrhea, calcium / phosphorus bone metabolism disorders and the like are available for prevention and treatment. |