http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2003135065-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6c8d4dc7bd1a30d8fda907fceaeb4e69 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 |
| filingDate | 2002-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31955e36eabbae27a3d4cdfb54ad8eff |
| publicationDate | 2003-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2003135065-A |
| titleOfInvention | Novel proteins and genes encoding them |
| abstract | (57) [Problem] To provide a novel protein useful for elucidating the molecular structure and function of glutamate receptor. Kind Code: A1 A gene encoding a variant of the NMDA-type glutamate receptor cDNA obtained from mouse cerebellum is prepared by site-directed mutagenesis. MRNA was synthesized from the variant gene, introduced into Xenopus oocytes and translated to obtain the above variant. EFFECTS OF THE INVENTION The modified NMDA-type glutamate receptor of the present invention provides neuronal signal transduction at synapses, expression of synaptic plasticity as a basis for memory and learning, and neuronal necrosis occurring in pathological conditions such as cerebral ischemia and status epilepticus. Elucidation, transmission mechanism of neural information in the center, higher-order structure of the brain, In addition to being useful for understanding the pathological condition of the brain, it is also useful for treating genetic diseases and creating new drugs. |
| priorityDate | 2002-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 735.