| abstract |
(57) [Summary] The present invention provides an antipruritic agent useful for treating pruritus in various pruritic diseases. SOLUTION: General formula (VI) [Wherein, X and Y are independently hydrogen or chlorine, and Z represents CH 2 , O, or S. In addition, the general formula (VI) includes (+)-form, (-)-form and (±) -form), and an opioid κ receptor agonist compound represented by the formula (I) or a pharmaceutically acceptable acid addition salt thereof is effective. Antipruritic as an ingredient. |