abstract |
(57) [Summary] (Modified) [PROBLEMS] To provide a nucleic acid encoding a steroid hormone and a thyroid hormone receptor protein. A substantially pure nucleic acid encoding a protein selected from the following (a), (b) and (c) is provided: (A) a protein consisting of an amino acid sequence defined by a specific sequence; (b) a protein consisting of an amino acid sequence defined by another specific sequence; (c) deletion or substitution of one or more amino acids Or a protein different from the protein of (a) or (b) by addition, The protein of (a) or (b) binds to glucocorticoid hormone with at least 10% of the glucocorticoid hormone binding activity, or binds to a glucocorticoid response element in a cis-trans bioassay using pGMCAT as the reporter plasmid. In some cases, said protein has at least 10% of the transcription activation activity of the protein of (a) or (b). |