| abstract |
(57) Abstract: The present invention has an excellent PDE4 inhibitory action, It is intended to provide a novel pyrazinoisoquinoline derivative useful as a prophylactic or therapeutic agent for asthma and the like. SOLUTION: General formula [I]: (In the formula, R 1 and R 2 are the same or different hydroxyl group or a lower alkoxy group, Ring A is a substituted benzene ring such as, R 3 Is a hydrogen atom, a group represented by the formula: — (CH 2 ) n —R 31 (where R 31 is a hydrogen atom, an aryl group, a hydroxyl group, an amino group, a carboxyl group, a lower alkoxycarbonyl group or a lower alkylthio group, and n is Represents an integer of 1 to 6), Or formula: a group represented by -CO-R 32 (where, R 32 Represents an aryl group, a lower alkyl group, a hydroxy lower alkyl group or an amino lower alkyl group). Or a pharmacologically acceptable salt thereof. |