| abstract |
(57) [Problem] To provide a therapeutic or preventive agent for a disease caused by the onset of muscular contraction / relaxation dysfunction such as heart failure based on the improvement of muscular contraction / relaxation dysfunction, and a therapeutic or prophylactic agent thereof. To provide an evaluation selection method useful for screening and its pharmacological evaluation. Kind Code: A1 The cause of the onset of muscle contraction / relaxation dysfunction comprising as an active ingredient a compound exhibiting an action of suppressing Ca 2+ leak from sarcoplasmic reticulum by improving and / or stabilizing ryanodine receptor function. A therapeutic or prophylactic agent for a disease that becomes; and sarcoplasmic reticulum, by contacting with a test substance, measuring Ca 2+ leak from the sarcoplasmic reticulum in the presence of the test substance, By improving and / or stabilizing ryanodine receptor function, A method for selecting a compound that exerts an action of suppressing Ca 2+ leak from the sarcoplasmic reticulum as a therapeutic or preventive agent for a disease that causes the onset of muscle contraction / relaxation dysfunction. . |