| abstract |
(57) [Summary] [PROBLEMS] A compound showing a remarkable and selective Rho kinase inhibitory effect, no problematic toxicity, good oral absorption and pharmacokinetics (drug absorption, distribution, metabolism, excretion, etc.), and a compound In addition, the present invention provides a therapeutic agent for various diseases associated with Rho kinase, which has good physical properties (stability and the like). SOLUTION: General formula (I) (In the formula, Ra represents a nitrogen-containing heterocyclic ring which may have a substituent, Rb represents hydrogen or the like, and Rc represents aryl or the like having the same or different 1 to 5 substituents.) An amide compound represented, an isomer thereof or a pharmaceutically acceptable salt thereof. |