http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2003070479-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1010e3862914acdd087e73d76911ec6d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate | 2001-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7f4de767cd09911f9efa2c833f0be5a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33db879af526fdb25c0696abe522e6ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4eb15cfed98dd2f66542b4292a15ece |
| publicationDate | 2003-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2003070479-A |
| titleOfInvention | SH2 domain mutant of Grb2 |
| abstract | [PROBLEMS] To provide an SH2 domain capable of binding a sequence containing a phosphorylated substituted tyrosine which is a phosphorylated unnatural amino acid, and to introduce a substituted tyrosine into an autophosphorylation site of a receptor. By using the mutant SH2 domain, a new artificial signal transduction pathway is constructed in which the presence or absence of phosphorylation of the non-natural tyrosine analog is switched in the cell. An amino acid sequence of a site that binds to a phosphorylated amino acid of an SH2 domain of an adapter protein is represented by the following: The present invention relates to an SH2 domain mutant modified to be able to bind more strongly to a peptide or protein containing a phosphorylated unnatural amino acid than to a phosphorylated natural amino acid, and to a method for producing the same. Adapter of the present invention Proteins can provide a novel artificial intracellular signaling system. The present invention relates to a novel intracellular signal transduction system using the aforementioned adapter-protein, and a method for constructing the same. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-100347307-C |
| priorityDate | 2001-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 219.