| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_832999f230974e686160c11f3929678d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-24222 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-52 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F17-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
| filingDate |
2002-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ad9e26e567f876b4026fac7b6049680
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a9b46d6a5e608217c1b9e9ce575f158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08bf43c314537fca9bc782bc7bd636dd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2db8ee348ae8b67c0293a7b46729e2a7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41c7525323c4d0bb8362968d546a2e4d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_faa6eb9b51873b2b10ec0159c5ddea88 |
| publicationDate |
2003-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2003061685-A |
| titleOfInvention |
Hepatitis C virus (HCV) NS5B RNA polymerase and mutants thereof |
| abstract |
[PROBLEMS] To clarify the three-dimensional information of a mutated NS5B RNA polymerase and a complex thereof with a compound, and to provide a small molecule inhibitor which is a novel therapeutic substance effective for the treatment of HCV. Regarding elucidation. Viral RNA polymerase is known to play a role in viral replication once the virus infects its host. The present invention The present invention relates to a mutant of the native hepatitis C virus (HCV) RNA polymerase, which confers improved crystallinity of enzymes and enzyme / compound complexes. The present invention further relates to the isolation and identification of an allosteric binding cleft in HCV NS5B RNA polymerase and its use in the discovery, identification and characterization of its inhibitors. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007534292-A |
| priorityDate |
2001-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |