| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8be6a6c990669567cc455d32b00535e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K2-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 |
| filingDate |
2002-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b55fd40e9b50fa626926a3097bc26bfb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a10db5632784f0ef6eeced99ad624bc6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d79c84a7dc98cff2ab6a1ec43dee0d5e |
| publicationDate |
2003-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2003055396-A |
| titleOfInvention |
Method for rapid solution synthesis of peptides |
| abstract |
(57) [PROBLEMS] To provide a high-speed solution synthesis method of oligo and polypeptide, In particular, we will develop a high-speed solution synthesis method with fewer by-products. The present invention relates to a method for rapid solution synthesis of peptides. The method comprises steps (a)-(d): (a) a coupling step in which an excess of activated carboxyl component is used to acylate the amino component, (b) residual activated carboxyl functionality using a scavenger. An elimination step where the capture agent is also used to deprotect the growing peptide, (C) one or more aqueous extraction steps, and (d) In some cases, an amine comprising a free anion or potential anion as a scavenger of the remaining activated carboxyl functional group, consisting of repeated cycles of independent deprotection steps inserted before one or more aqueous extraction steps Including at least one step (b) that uses the term "step (b ')". The method of the present invention does not require isolation of the growing peptide until the final peptide sequence is obtained. This extremely efficient method is useful for the production of high purity oligo- and polypeptides. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7063408-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021192488-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021132545-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019198833-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9334302-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11098078-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9346850-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007099656-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11420997-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8716439-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-5171613-B2 |
| priorityDate |
2001-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |