| abstract |
(57) [Problem] To provide a method for determining the absolute configuration of an optically active substance, which can determine the absolute configuration even if the compound has no crystallinity or the sample has no margin. SOLUTION: An optically active trans-2-arylcycloalkane-1-ol [I] is condensed with an optically active carboxylic acid having a known absolute configuration or a derivative thereof [II] to form a condensate. Get [III]. By measuring the chemical shift of the methyl group at the 2-position on the cyclic skeleton by 1 H NMR analysis of the condensate, an optically active trans-2-arylcycloalkane- Determine the absolute configuration of the 1-ols. In each formula, Ar is an aromatic carbocyclic group or an aromatic heterocyclic group or an aralkyl group, and n is 3 to 5. In the formula [II], the configuration of the carboxyl group at the 1-position or its derivative group and the methyl group at the 2-position is cis, X Is OH, alkoxy, halogen. Embedded image |