| abstract |
(57) [Summary] (Modified) [Problem] To provide a compound that exhibits excellent CCR5 antagonism and is useful as a prophylactic / therapeutic agent for HIV infection of human peripheral blood mononuclear cells, particularly AIDS. SOLUTION: Equation 1, (In the formula, R 1 and R 2 represent a hydrogen atom, a hydrocarbon group, a non-aromatic heterocyclic ring, or R 1 and R 2 may be bonded to form a heterocyclic ring with a nitrogen atom; N or N + -R 5 • Y − (R 5 represents a hydrocarbon group, Y − represents a counter anion), R 3 represents a cyclic hydrocarbon group or a heterocyclic ring, n represents 0 or 1, R 4 represents a hydrogen atom, a hydrocarbon Group, A heterocyclic ring, an alkoxy group, an aryloxy group, or an amino group; E represents a divalent chain hydrocarbon group other than an oxo group; G 1 is a bond, CO or SO 2 , G 2 is CO, SO 2 , NHCO, CONH or OCO, J is a methine or nitrogen atom, Q and R are each a divalent C 1-3 Each chain hydrocarbon is shown. Or a salt thereof. |