| abstract |
(57) Abstract: A compound represented by the formula (1) or a physiologically acceptable salt thereof, and a medicament comprising the same as an active ingredient. Embedded image (R 1 represents a halogen atom or a phenyl group or a C 1 -C 8 alkyl group which may be substituted with a C 1 -C 4 alkyl group, R 2 represents a hydrogen atom or a C 1 -C 4 alkyl group, R 3 represents a C 2 -C 6 alkyl group, and R 4 represents a partial structural formula 1 or 2.) Embedded image (R 5 represents a hydrogen atom or a triphenylmethyl group, R 6 Is a hydrogen atom, C 3 -C 5 alkyl group or which may have a substituent phenylaminocarbonyl group. [Effect] Biphenyl ureide derivative of the present invention (1) Has excellent angiotensin II receptor antagonism and acyl coenzyme A cholesterol acyltransferase inhibitory activity, and is used as a medicament for preventing and / or treating diseases caused by complications of hypertension and hyperlipidemia and complications. Useful. |