| titleOfInvention |
Peripheral nervous system specific sodium channel, DNA encoding it, crystallization, X-ray diffraction, computer molecular modeling, rational drug design, drug screening, and methods of making and using the same |
| abstract |
(57) Abstract: To provide a diagnosis and / or treatment of a medical condition related to impaired PNS neurotransmission. At least one peripheral nervous system specific (PNS) Therapeutic or diagnostic agents or ligands having sodium channel (SC) modulating activity are isolated, crystallized, X-ray analytical molecular modeling, rational drug design, selection, manufacture and use for at least one peripheral component. Cloning, expression, viral and delivery vectors and hosts comprising nucleic acids encoding nervous system specific (PNS) sodium channel peptides (SCPs), isolated PNSSCPs, and compounds and compositions and methods are provided. |