abstract |
(57) [Summary] [PROBLEMS] To identify biological substances involved in the regulation of bone (or cartilage) formation and osteoblast (or chondrocyte) differentiation, A screening means for a substance capable of regulating the biological activity of the biological substance is provided, thereby providing a drug having an excellent preventive / therapeutic effect on a bone disease. SOLUTION: NRH: quinone oxidoreductase (NQO) 2) A method for screening a compound having an effect on bone or a salt thereof characterized by using a partial peptide or a salt thereof, and a bone action agent containing the compound obtained by the method. Further, the present invention provides a method for preventing or treating bone disease in humans or mammals, which comprises inhibiting or promoting the expression or activity of NQO2. Further, the present invention provides a diagnostic agent for bone disease, comprising a polynucleotide encoding NQO2 or a partial peptide thereof, or an antibody having specific affinity for NQO2, a partial peptide thereof, or a salt thereof. |