| abstract |
(57) [Summary] (Modified) [PROBLEMS] To provide a method for selecting a dopamine D4 receptor binding ligand candidate compound. The method is performed in the following steps. 1) Determine the stable conformation of the test compound. 2) The stable conformation is of formula (1): [Wherein E is a hydrophobic partial structure, b is a center of gravity on E, G Is an aromatic ring, a is the center of gravity of G, A is a carbon atom or a nitrogen atom, J is a nitrogen-containing aliphatic heterocyclic ring, and x is 30 in the distance between a and b. -40, y is the distance between the nitrogen atom on J and b, 50-60, U is the angle between the line connecting a and b and the normal l perpendicular to S −62 degrees] is evaluated for conformity to the model. 3) The matched compound is used as a candidate dopamine D4 receptor ligand. |