| abstract |
[PROBLEMS] To provide a protein having highly stable human thrombopoietin (TPO) activity. In an amino acid sequence containing at least the amino acid residues at positions 7 to 151 of a specific amino acid sequence, simultaneous substitution of at least a proline residue at position 38 and an alanine residue at position 120 with a cysteine residue is performed. A protein having human TPO activity, a DNA encoding the protein, a vector and a host cell containing the DNA, a method for producing the protein, and a pharmaceutical composition containing the protein. |