| abstract |
(57) [Summary] (Modifications) [PROBLEMS] To provide a novel method for synthesizing cyclopram having serotonin reuptake inhibitor and having antidepressant activity. SOLUTION: General formula IV Wherein R represents C 1-6 alkyl, acyl, C 1-6 alkylsulfonyl or arylsulfonyl, and reacting the compound with 3- (N, N-dimethylamino) propylmagnesium halide; A citalopram of the formula I is produced. |