| abstract |
(57) [Problem] To provide a novel mevastatin derivative which is expected to have an excellent inhibitory action on 3-hydroxy-3-methylglutaryl-coenzyme A reductase. SOLUTION: General formula (I) (In the formula, R 1 and R 2 represent a hydrogen atom or a hydroxyl group, except that both R 1 and R 2 are hydrogen atoms.) The mevastatin derivative of the present invention is a microorganism belonging to the genus Streptomyces and having an activity of hydroxylating the 3 "or 4" position of mevastatin, for example, Streptomyces sp. TM-6 strain or TM-7 The strain can be produced by culturing the strain, adding mevastatin to the culture solution or a solution containing cells separated from the culture solution, and reacting it. |