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filingDate 2001-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_447e7d8e70a1bdbe7b58992a1c8062cf
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publicationDate 2003-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2003012503-A
titleOfInvention Methods for immobilizing lipid vesicles and genes
abstract (57) [Problem] A liposome used as a conventional gene carrier has problems in stability and metabolism, and is expensive and expensive. Solving the problem that it is difficult to use as DS, stability, Provided is a method for immobilizing lipid vesicles and genes as DDS which is excellent in metabolism and is inexpensive. SOLUTION: A cationic peptide lipid is added to an artificial lipid constituting a lipid vesicle, the surface of the lipid vesicle is made to have a positive polarity so that DNA can be easily attached thereto, and a nucleic acid binding protein such as histone is added to a plasmid gene. A method for immobilizing a gene on a lipid vesicle after improving the transfection efficiency realizes a gene immobilization method that is excellent in stability and metabolism, is inexpensive, and has high transfection efficiency.
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