| abstract |
(57) [Problem] To provide a novel pharmaceutical use using a MITF mutant. SOLUTION: An agent for inducing mast cell death, comprising a fusion protein composed of PDT and a mutant MITF as an active ingredient, and HisTag, PTD and MI In a fusion protein composed of TF variants, MIT The F mutant is a mi mutant, a wh mutant or b of MITF The fusion protein, which is an HLH-Zip fragment. The fusion protein of the present invention inhibits the activity of endogenous MITF by translocating into mast cells, inhibits differentiation of mast cells from precursor cells, inhibits mast cell survival, and kills mast cells ( Apoptosis). |