| abstract |
(57) [Summary]nThe present invention relates to substituted azetidin-2-ones and pharmaceutical compositions containing the compounds. Furthermore, it relates to the use of said compounds in medicine as inhibitors of cysteine proteases, in particular cathepsins. The present invention includes a compound of Formula (I), or a pharmaceutically acceptable salt, hydrate, or solvate of the compound. In the above formula, Y is -C (O)-or -S (O Two )-, Wherein R is allyl (ie, CH Two = CHCH Two -) Represents a group or a radical; 1 Is -OCOR Five , -OR Five , -SR Five , -S (O) R Five Or -S (O) Two R Five And R Two Represents a radical; R Three Is -OR Five Or R Five RepresentsnEmbedded image |