http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002543155-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-567 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-537 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-536 |
| filingDate | 2000-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2002543155-A |
| titleOfInvention | Antiprogestin and contraceptive composition containing progestin |
| abstract | (57) [Summary] The present invention provides a compound of the general structure (I): Wherein R 1 and R 2 are a single substituent or can be fused to form a spirocyclic or heterospirocyclic ring; R 3 is H, OH, NH 2 , C 1 -C 6 alkyl, substituted C 1 -C 6 alkyl, C 3 -C 6 alkenyl, substituted C 1 -C 6 alkenyl, alkynyl or substituted alkynyl, be a COR C; R C is H, C 1 -C 3 alkyl, substituted C 1 -C 3 alkyl, aryl, substituted aryl, C 1 -C 3 alkoxy, substituted C 1 -C 3 alkoxy, C 1 -C 3 aminoalkyl or substituted and C 1 -C be 3 aminoalkyl; R 4 is H, halogen, CN, NO 2, C 1 ~C 6 alkyl, substituted C 1 -C 6 alkyl, alkynyl or substituted alkynyl, C 1 ~ C 6 alkoxy, C 1 substituted -C 6 alkoxy, amino, C 1 -C 6 aminoalkyl or substituted C 1 Be a C 6 aminoalkyl; and R 5 is a benzene ring which is trisubstituted, or O, S, SO, have 1, 2 or 3 heteroatoms from the group comprising SO 2 or NR 6 and H,, halogen, CN, NO 2, amino, and C 1 -C 3 alkyl, C 1 -C 3 alkoxy and C 1 -C 3 aminoalkyl, and one or two independent from the group comprising COR F or NR G COR F Cyclic combination therapy and regimen utilizing a substituted indoline derivative compound which is a progesterone receptor antagonist having a substituent selected from a 5- or 6-membered ring, or a pharmaceutically acceptable salt thereof. About. These methods of treatment are for contraception or for secondary amenorrhea, dysfunctional bleeding, uterine leiomyoma, endometriosis; polycystic ovary syndrome, endometrial, ovarian, breast, colon, prostate cancer and It can be used to treat and / or prevent adenocarcinoma or to minimize side effects or periodic menstrual bleeding. Further uses of the invention include stimulation of food intake. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011520799-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8309594-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007534760-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8609712-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009511512-A |
| priorityDate | 1999-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 223.