| abstract |
(57) [Summary]nThe present invention relates to antibodies or antigen-binding fragments thereof that bind to the CC chemokine receptor GPR-9-6 and block the binding of a ligand (eg, TECK) to the receptor. The invention also relates to the identification of agents (molecules, compounds) that can bind to GPR-9-6, inhibit the binding of ligands (eg, TECK), and / or modulate the function of GPR-9-6. About the method. The present invention further relates to the use of the antibodies, antigen-binding fragments and agents identified by the methods of the invention in methods of modulating the function of GPR-9-6, and in methods of research, treatment, prevention and diagnosis. |