| abstract |
(57) [Summary]nThe present invention provides a compound of formula (I):nEmbedded imagen And a method for producing a 1-nitro-3-substituted-3-amino-2-propanol diastereomer represented by the formula: In structural formula (I), R is an amine protecting group, and R 1 Is an amino acid side chain, a protected amino acid side chain, a substituted or unsubstituted aliphatic group, a substituted or unsubstituted aromatic group, a substituted or unsubstituted heteroaromatic group, a substituted or unsubstituted aralkyl or a substituted or unsubstituted It is a substituted heteroaralkyl group. The method comprises contacting the 1-nitro-3-substituted-3-amino-2-propanone with a reducing agent to form a mixture of 1-nitro-3-substituted-3-amino-2-propanol diastereomers. including. The 1-nitro-3-substituted-3-amino-2-propanol diastereomer is then separated by simulated moving bed chromatography and one or more 1-nitro-3-substituted-3-amino-2-propanols Diastereomers are obtained. |