| abstract |
(57) Abstract: (i) wild-type PAR-2 compared to the have a reduced sensitivity to trypsin; heightened for (ii) as compared to wild-type PAR-2 trans- cinnamoyl -LIGRLO-NH 2 has a sensitivity; and (iii) activated by TLIGRL-NH 2, mutant PAR-2 receptor polypeptide or fragment thereof is provided, wherein the polypeptide or fragment thereof, the corresponding ECL of wild-type polypeptide -2 comprises extracellular loop-2 (ECL-2) having at least one amino acid difference from the amino acid sequence. |