| abstract |
(57) Abstract Animals, such as transgenic mice, in which the MSH5 gene is mis-expressed, which is useful for screening therapeutics for a number of conditions. Further, a method for evaluating a therapeutic method evaluated in vivo or in vitro, the method comprising administering the therapeutic method to an MSH5-misexpressed animal or a cell derived therefrom, and determining the effect of the therapeutic method on a fertility index. And thereby evaluating said reproductive method. It also describes how to identify contraceptives. |