| abstract |
(57) SUMMARY The present invention provides sorbitol dehydrogenase inhibiting compounds of Formula I. Embedded image R 1 , R 2 and R 3 in the formula are as defined in the description. The invention also relates to pharmaceutical compositions containing such compounds, diabetic neuropathy, diabetic retinopathy, diabetic nephropathy, diabetic cardiomyopathy, diabetic microangiopathy, and diabetic arteriosclerosis. The use of the compounds of the formula I The invention is further directed to a pharmaceutical composition comprising a combination of a sorbitol dehydrogenase inhibitor of formula I and an aldose reductase inhibitor, and a method for treating or preventing diabetic complications in a mammal. The use of different compositions. The present invention also relates to certain intermediates in the synthesis of the compounds of formula I, and to methods for making such intermediates. |