http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002539451-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-04 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-536 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-567 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B30-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B40-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B50-06 |
| filingDate | 2000-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2002539451-A |
| titleOfInvention | Method for measuring ligand / target affinity promoted by centrifugation |
| abstract | (57) Abstract Centrifugation is used to induce and / or enhance the binding of macromolecular targets to small molecule ligands or larger biomolecules (alone or as a mixture). Due to the enhanced binding, the method of the present invention allows for the detection of a ligand that binds to a target substance and enhances the design of the ligand. The method is based on centrifugal force that establishes a differential and selective concentration gradient between the macromolecular therapeutic target and the desired ligand. Once formed, information about the self-sorting binding event is derived by analyzing the differential gradients of macromolecules and ligands in situ, or by fractionating the gradient into individual samples for further analysis. I do. Various methods or combinations thereof can be used to find enhanced binding ligand levels. |
| priorityDate | 1999-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 168.