| abstract |
(57) Abstract: Compounds that bind to the alpha 4 beta 7 integrin is disclosed. Certain of these compounds also leukocyte adhesion, inhibit leukocyte adhesion mediated by particularly alpha 4 beta 7 integrin. Such compounds are useful in mammalian patients (eg, humans) for inflammatory diseases (eg, asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis) And myocardial ischemia). The compounds can also be administered for the treatment of inflammatory brain diseases (eg, multiple sclerosis). |