| abstract |
(57) [Summary]nThe present invention provides immunoglobulin molecules that bind SI (KDR) with an affinity comparable to human VEGF and neutralize KDR activation. Immunoglobulin molecules include monovalent single chain antibodies, multivalent single chain antibodies, diabodies, triabodies, antibodies, humanized antibodies and chimeric antibodies. The present invention further provides nucleic acid molecules encoding these immunoglobulin molecules. The present invention also provides a method for producing the above-mentioned immunoglobulin molecule. The present invention further provides a method for neutralizing KDR activation using such immunoglobulins, a method for suppressing neovascularization in mammals, and a method for suppressing tumor growth in mammals. |