| abstract |
(57) [Summary] The present invention relates to an anti-emetic composition for transdermal administration for the treatment and prevention of emesis and a preparation containing the same, and more specifically, (a) (1) hydrophilicity 20 to 80% by weight of an organic solvent, (2) 1 to 50% by weight of a skin permeation enhancer selected from the group consisting of fatty acids and derivatives thereof, fatty acid alcohols and derivatives thereof, amide compounds, terpene compounds, surfactants and mixtures thereof %, And (3) a base for transdermal administration containing 15 to 80% by weight of water; and (b) 1 to 15% by weight of tropisetron, ondansetron, granisetron and 100% by weight of the base. An antiemetic drug selected from the group consisting of their effective salts, which is passed through the skin at an effective rate, is maintained at an effective blood concentration for about 1 day or more, and has no skin irritation. Yo Antiemetic composition for the prevention and relates percutaneous preparation containing the same. |