| abstract |
(57) [Summary]nA novel S-nitrosothiol derivative of penicillamine or glutathione, wherein the S-nitrosothiol derivative corresponds to the following general formula:nEmbedded imagen In this formula: A and B are phenyl groups or -CH which together form a 6-membered ring Two -Q-CH Two -Residue, -CH Two -Q-CH Two In-, Q represents an oxygen atom, a sulfur atom or NR Three Represents a group, NR Three At R Three Is hydrogen or an alkyl group having 1 to 4 carbon atoms: R 1 Is an acyl residue; 1 May be a residue of glutamic acid linked via an aliphatic acyl group having 1 to 5 carbon atoms or a non-amino acid carboxyl: R Two Is a glycine residue linked via a hydroxyl group or a peptide bond: 1 Is an aliphatic acyl residue, Two Is a hydroxyl group, and R 1 Is a residue of glutamic acid, R Two Is a glycine residue. The novel compounds have vasodilator activity and also inhibit platelet aggregation, which makes them useful for treating dysfunction at the circulatory system, especially at the cardiovascular level. |