| abstract |
The present invention relates to novel compounds that inhibit blood coagulation proteins, and more particularly, to R (1), R (2), R (3), R (4), R (5) And R (6a), R (6b) have the meaning defined in the claims. The compounds of formula (I) are inhibitors of blood coagulation enzyme factor Xa. The present invention also provides a method of preparing a compound of formula (I), a method of inhibiting the activity of factor Xa and a method of inhibiting blood coagulation, a disease of a compound of formula (I) (a disease which can be treated or prevented by inhibiting the activity of factor Xa, for example, (Thromboembolism) and the use of the compounds of formula (I) for the manufacture of a medicament for such a disease. The invention furthermore relates to compositions comprising a compound of the formula (I) mixed or combined with an inert carrier, in particular pharmaceutical compositions containing a compound of the formula (I) together with pharmaceutically acceptable carrier substances and auxiliary substances. About. Embedded image |