| abstract |
(57) compounds of summary formula (1.0) are disclosed, wherein, R 13 represents an imidazole ring; R 14 represents a carbamate, urea, amide or sulfonamide group; R 8 is represents H when the alkyl chain between the amide group and R 13 imidazole group is substituted, or R 8 represents an arylalkyl, substituents such as heteroarylalkyl or cycloalkyl; and the remaining Substituents are as defined herein. Also disclosed are compounds wherein R 8 is H and the alkyl chain between the amide group and the R 13 imidazole group is unsubstituted. Also disclosed are methods of treating cancer and inhibiting farnesyl protein transferase using the disclosed compounds. |