http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002533092-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1029 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P35-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-82 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10 |
| filingDate | 1999-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2002533092-A |
| titleOfInvention | Improved in vivo production of cephalosporins |
| abstract | (57) [Summary]nThe present invention provides a method for transforming a P. chrysogenum strain that has been transformed with an expression construct comprising a nucleotide sequence encoding an expandase, hydroxylase and acetyltransferase activity in the presence of a suitable acyl side chain precursor, or a salt or ester thereof. Fermenting so that an N-acylated 7-ACA compound is produced, a step of N-deacylating the N-acylated 7-ACA compound thus produced, and optionally a free amino group. A method for producing 7-ACA or a derivative thereof comprising the step of acylating and / or substituting the 3 'acetate group with a side chain suitable for forming a cephalosporin antibiotic, comprising: Is derived from Acremonium chrysogenum and the second of the open reading frame present in the nucleotide sequence is Disclosed is said method, characterized by starting with ATG. |
| priorityDate | 1998-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 124.