| abstract |
(57) [Summary]nThe present invention relates to a cyclization reaction of (2S) -1-{[[4-chloro-2- (2-chlorobenzoyl) phenyl]-(3,4-dimethoxybenzenesulfonyl) amino] acetyl} pyrrolidine-2-carboxamide. (2S) -1-[(2R, 3S) -5-chloro-3- (2-chlorophenyl) -1- (3,4-dimethoxybenzenesulfonyl) -3-hydroxy-2,3-dihydro-1H -Indole-2-carbonyl] pyrrolidine-2-carboxamide, a method for producing a solvate and / or hydrate thereof. The method is characterized in that it comprises cyclization with an alkali metal hydroxide in polyethylene glycol having an average molecular weight in the range from 200 to 600, mixed with water. |